The Evolving Landscape of Myelodysplastic Syndrome Prognostication
نویسندگان
چکیده
منابع مشابه
Perspectives in the prognostication of myelodysplastic syndromes.
Since the first precise definition of myelodysplastic syndromes (MDS) in 1982, prognostication of this disease has been a matter of debate. It very quickly became clear that the prognosis of MDS patients cannot be assessed by a single parameter, although the prognostic impact of the FAB classification, which is based on bone marrow morphology, is still impressive. This reflects the fact that th...
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Acquired aplastic anaemia is a clonal disorder of multifactonal origin. The ~pathophysiology of this disorder is still not clear Presumably the multiple incriminating factors include an intrinsic derangement of haematopoiesis, immune mediated damage to bone marrow and genetic predisposition. The long term complications of the aplastic anaemia include clonal evolution into disorders like Paroxys...
متن کاملDiagnostics and Prognostication of Myelodysplastic Syndromes
MDS are a heterogeneous and complex group of clonal hematological neoplasms arising from a hematopoietic stem cell, and characterized by ineffective hematopoiesis, resulting in increased apoptosis in the bone marrow and peripheral cytopenia, which involves one or more lineages. Epigenetic changes are reported as 'founder' mutations in the case of MDS. Its incidence in the general population has...
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UNLABELLED Over the past few years, large-scale genomic studies of patients with myelodysplastic syndrome (MDS) and acute myelogenous leukemia (AML) have unveiled recurrent somatic mutations in genes involved in epigenetic regulation (DNMT3A, IDH1/2, TET2, ASXL1, EZH2 and MLL) and the spliceosomal machinery (SF3B1, U2AF1, SRSF2, ZRSR2, SF3A1, PRPF40B, U2AF2, and SF1). The identification of thes...
متن کاملMyelodysplastic syndrome.
The last decade has witnessed a multistep evolution in the understanding of the natural history, clinical manifestations, and some of the molecular mechanisms that underlie the ineffective hematopoiesis and leukemic transformation in the myelodysplastic syndrome (MDS). The international prognostic scoring system, FAB, and WHO classifications have helped define specific subgroups with their char...
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ژورنال
عنوان ژورنال: Clinical Hematology International
سال: 2020
ISSN: 2590-0048
DOI: 10.2991/chi.d.200408.001